看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
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Currently available feasibility data for possible combination strategies. , |2 y6 k: ^* S2 o' o" v
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Combination Feasibility according to preliminary data ! o4 O$ i& e @! R
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, V9 R1 F, p0 f' i8 MBevacizumab + sorafenib Yes, reduced dose
% B m- C, h( b( ~" j% @8 K. iBevacizumab + sunitinib† No * w# o4 c, M2 w, S- }9 d
Bevacizumab + temsirolimus Yes
0 p; v" i# q/ R( I9 i( k! q# YBevacizumab + everolimus Yes
/ S) U* h/ p" s# U8 |Sorafenib + sunitinib ?
% K0 `. M1 t) ^8 o% D" BSorafenib + temsirolimus Yes, reduced dose
8 O! Z/ x2 M; E# {" p2 p1 l$ OSorafenib + everolimus Yes, reduced dose
& f' U, X8 F. vSunitinib + temsirolimus† No ) V5 V9 p P( n1 {
Sunitinib + everolimus ?
8 K( a3 H- ~, n7 g) s, b9 WTemsirolimus + everolimus ? + W" k. l" w( ~* `
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†Led to US FDA warning.
2 Y# e# X) |4 O?: As yet unattempted combination.
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