发给老马备查:
4 R0 w) ?5 z* E滴水察海(69304838) 15:23:23
$ g; \3 ^( x+ _8 C老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱- e4 m- T3 m9 M8 V2 m v
吉非替尼和S-1连用的依据; O+ a, V" [, C7 {
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
7 h: S2 F$ U" }' p# Y/ V4 I) {是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
I5 o- V, a: X7 B, m这样是不是推理出,耐药后,可以用S-1和培美了?% M% Q: \1 G _5 x
结论:0 r* I6 X5 k$ `9 B
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |