发给老马备查:# |% d" q' X0 |3 a$ d+ |: S, c! y
滴水察海(69304838) 15:23:23; z3 }! }6 F* X# ~+ i
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱- d, w, x, {4 ~" ^1 o
吉非替尼和S-1连用的依据
( v. H7 a5 H: ]- ~! wGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
5 L# h2 B0 n# q6 B" M- e8 r是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达" C+ ]2 ^5 R2 M! x# _. S2 Y
这样是不是推理出,耐药后,可以用S-1和培美了?; a( \ s4 A# H, ~. H
结论:
! Z* a, v# e( o1 F3 A& P如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |