发给老马备查:$ d4 X$ z% n7 P8 l" ~; A T* a/ H
滴水察海(69304838) 15:23:23
: _0 m9 ~: i3 }& Z+ P! k老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱6 @! ?) R3 W! i4 r2 ?/ w
吉非替尼和S-1连用的依据, a# [5 J( H b6 \% Q
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.8 @1 ^- b* W1 d/ y6 n
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
8 @( I3 t- ]1 r2 `% l/ t这样是不是推理出,耐药后,可以用S-1和培美了?8 k1 o2 k+ m, L0 H+ o4 }
结论:1 k* i# P2 ]3 |1 c' c9 E
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |