脑部放疗，上午比下午敏感许多！
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Cancer 2011 Jan 15;117(2):414-20. doi: 10.1002/cncr.25423. Epub 2010 Sep 9.
$ d* D) h) g: g) fGamma knife radiosurgery for brain metastasis of nonsmall cell lung cancer: is there a difference in outcome between morning and afternoon treatment?0 B$ }+ Z0 N7 I/ \8 J1 B
Rahn DA 3rd, Ray DK, Schlesinger DJ, Steiner L, Sheehan JP, O'Quigley JM, Rich T.
/ K5 X' L, u1 {* r7 HSourceDepartment of Radiation Oncology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA.0 Q& Q: V" [: M, `$ \ o
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Abstract
7 N9 k0 j. j7 b4 Y2 `BACKGROUND: Circadian cell-cycle progression causes fluctuating radiosensitivity in many tissues, which could affect clinical outcomes. The purpose of this study was to determine whether outcomes of single-session gamma knife radiosurgery (GKRS) for metastatic nonsmall cell lung cancer (NSCLC) differ based on treatment time.
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METHODS: Fifty-eight patients received GKRS between 10:00 am and 12:30 pm and 39 patients received GKRS between 12:30 pm and 3:00 pm. The mean peripheral dose was 18.6 Gy. The mean tumor size was 7.3 cm³. Magnetic resonance imaging was used to score local control at 3 months. Cause of death (COD) was categorized as central nervous system (CNS)-related or systemic.' X* E0 m) _3 b* i; o- B( a$ C
# |) V+ c% i7 I* pRESULTS: Demographic and disease characteristics of the 2 groups were similar. Local control at 3 months was achieved in 97% (35/36) of patients who underwent GKRS early in the day versus 67% (8/12) of patients who underwent GKRS later in the day (chi-square, P = .014). Early GKRS was associated with better survival (median 9.5 months) than late GKRS (median 5 months) (Kaplan-Meier log-rank test, P = .025). Factors contributing to better survival in a Cox regression model included early treatment time (P = .004) and recursive partition analysis class (P < .001). Cause of death in the early treatment group was CNS-related in 6% (3/47) of patients versus 24% (8/34) of patients in the late treatment group (chi-square test, P = .026).( H; E+ q0 M2 T5 d" H7 e
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CONCLUSIONS: GKRS for metastatic NSCLC had better local control, better survival, and a lower rate of CNS-related cause of death when given earlier in the day versus later in the day. These retrospective data should encourage future study in brain radiosurgery and non-CNS stereotactic body radiotherapy series.) Q" W! L8 y9 K7 @) N( _
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依沃西联培美两周期复查
靶向药耐药后 第一次化免21天查cea没什么变化，这次复查降了一半，肿瘤五项指标都不同
奥西替尼耐药后续治疗，出现腹水
治疗经过：
2010确诊腺癌
治疗方案：右肺上叶切除，10年民诺宾2次，顺铂+盖诺2次。
最被低估的抗肿瘤运动！比游泳、慢跑
作者：Tony
今年春晚舞台上，机器人都跳上舞了，动作整齐，科技感十足，网友们也纷纷
“振”守脑膜，为生命开辟逆袭航道丨
脑膜转移，常被广大病友称为“终极转移”——癌细胞犹如乘坐“特快列车”，沿脑脊液扩
妈妈肺腺9年，现在迷茫请大神路过给
病情大体介绍，患者女现69周岁，有吸烟史50年，2003年感冒憋气，CT显示肺部有片炎症，
显身卡
